| PSV Eindhoven 2009-2010 |
| August |
| Sun. 2 | 7:30 AM PT8:30 AM MT9:30 AM CT10:30 AM ET2:30 PM GMT16:30 CET15:30 | H | VVV-Venlo | Philipsstadion | D 3-3 |
| Sun. 9 | 5:30 AM PT6:30 AM MT7:30 AM CT8:30 AM ET12:30 PM GMT14:30 CET13:30 | A | FC Twente | De Grolsch Veste | D 1-1 |
| Sun. 16 | 3:30 AM PT4:30 AM MT5:30 AM CT6:30 AM ET10:30 AM GMT12:30 CET11:30 | H | Ajax | Philipsstadion | W 4-3 |
| Sun. 23 | 5:30 AM PT6:30 AM MT7:30 AM CT8:30 AM ET12:30 PM GMT14:30 CET13:30 | H | NAC Breda | Philipsstadion | W 3-1 |
| Sun. 30 | 5:30 AM PT6:30 AM MT7:30 AM CT8:30 AM ET12:30 PM GMT14:30 CET13:30 | A | FC Groningen | Euroborg | W 2-0 |
| |
| September |
| Sat. 12 | 9:45 AM PT10:45 AM MT11:45 AM CT12:45 PM ET4:45 PM GMT18:45 CET17:45 | H | Roda JC | Philipsstadion | W 3-0 |
| Sun. 20 | 5:30 AM PT6:30 AM MT7:30 AM CT8:30 AM ET12:30 PM GMT14:30 CET13:30 | A | Feyenoord | De Kuip | W 3-1 |
| Sat. 26 | 10:45 AM PT11:45 AM MT12:45 PM CT1:45 PM ET5:45 PM GMT19:45 CET18:45 | H | Willem II | Philipsstadion | W 3-1 |
| |
| October |
| Sun. 4 | 5:30 AM PT6:30 AM MT7:30 AM CT8:30 AM ET12:30 PM GMT14:30 CET13:30 | A | FC Utrecht | Nieuw Galgenwaard | D 0-0 |
| Sat. 17 | 11:45 AM PT12:45 PM MT1:45 PM CT2:45 PM ET6:45 PM GMT20:45 CET19:45 | H | SC Heerenveen | Philipsstadion | W 1-0 |
| Sun. 25 | 8:30 AM PT9:30 AM MT10:30 AM CT11:30 AM ET3:30 PM GMT16:30 CET15:30 | A | NEC Nijmegen | De Goffert | W 4-0 |
| Sat. 31 | 11:45 AM PT12:45 PM MT1:45 PM CT2:45 PM ET6:45 PM GMT19:45 CET18:45 | H | Vitesse | Philipsstadion | W 1-0 |
| |
| November |
| Sun. 8 | 5:30 AM PT6:30 AM MT7:30 AM CT8:30 AM ET1:30 PM GMT14:30 CET13:30 | A | ADO Den Haag | ADO Stadion | W 5-1 |
| Sun. 22 | 7:30 AM PT8:30 AM MT9:30 AM CT10:30 AM ET3:30 PM GMT16:30 CET15:30 | H | Heracles Almelo | Philipsstadion | W 4-0 |
| Fri. 27 | 11:45 AM PT12:45 PM MT1:45 PM CT2:45 PM ET7:45 PM GMT20:45 CET19:45 | A | Sparta | Het Kasteel | |
| |
| December |
| Sun. 6 | 5:30 AM PT6:30 AM MT7:30 AM CT8:30 AM ET1:30 PM GMT14:30 CET13:30 | A | RKC Waalwijk | Mandemakers | |
| Sat. 12 | 11:45 AM PT12:45 PM MT1:45 PM CT2:45 PM ET7:45 PM GMT20:45 CET19:45 | H | AZ Alkmaar | Philipsstadion | |
| Sun. 20 | 7:30 AM PT8:30 AM MT9:30 AM CT10:30 AM ET3:30 PM GMT16:30 CET15:30 | A | Roda JC | Parkstad Limburg | |
| |
| January |
| Fri. 22 | 11:45 AM PT12:45 PM MT1:45 PM CT2:45 PM ET7:45 PM GMT20:45 CET19:45 | H | NEC Nijmegen | Philipsstadion | |
| Sun. 31 | 5:30 AM PT6:30 AM MT7:30 AM CT8:30 AM ET1:30 PM GMT14:30 CET13:30 | A | Vitesse | Gelredome | |
| |
| February |
| Wed. 3 | 11:00 AM PT12:00 PM MT1:00 PM CT2:00 PM ET7:00 PM GMT20:00 CET19:00 | H | FC Utrecht | Philipsstadion | |
| Sat. 6 | 9:45 AM PT10:45 AM MT11:45 AM CT12:45 PM ET5:45 PM GMT18:45 CET17:45 | H | ADO Den Haag | Philipsstadion | |
| Sun. 14 | 5:30 AM PT6:30 AM MT7:30 AM CT8:30 AM ET1:30 PM GMT14:30 CET13:30 | A | Heracles Almelo | Polman Stadion | |
| Sat. 20 | 11:45 AM PT12:45 PM MT1:45 PM CT2:45 PM ET7:45 PM GMT20:45 CET19:45 | H | Sparta | Philipsstadion | |
| Sat. 27 | 10:45 AM PT11:45 AM MT12:45 PM CT1:45 PM ET6:45 PM GMT19:45 CET18:45 | H | RKC Waalwijk | Philipsstadion | |
| |
| March |
| Sat. 6 | 11:45 AM PT12:45 PM MT1:45 PM CT2:45 PM ET7:45 PM GMT20:45 CET19:45 | A | NAC Breda | Rat Verlegh Stadion | |
| Sun. 14 | 8:30 AM PT9:30 AM MT10:30 AM CT11:30 AM ET3:30 PM GMT16:30 CET15:30 | A | Ajax | Amsterdam ArenA | |
| Sat. 20 | 11:45 AM PT12:45 PM MT1:45 PM CT2:45 PM ET6:45 PM GMT19:45 CET18:45 | H | FC Twente | Philipsstadion | |
| Sun. 28 | 5:30 AM PT6:30 AM MT7:30 AM CT8:30 AM ET12:30 PM GMT13:30 CET12:30 | A | VVV-Venlo | Seacon Stadion - De Koel | |
| |
| April |
| Sun. 4 | 5:30 AM PT6:30 AM MT7:30 AM CT8:30 AM ET12:30 PM GMT13:30 CET12:30 | A | Willem II | Stadion Willem II | |
| Sun. 11 | 3:30 AM PT4:30 AM MT5:30 AM CT6:30 AM ET10:30 AM GMT11:30 CET10:30 | H | Feyenoord | Philipsstadion | |
| Wed. 14 | 11:00 AM PT12:00 PM MT1:00 PM CT2:00 PM ET6:00 PM GMT19:00 CET18:00 | A | SC Heerenveen | Abe Lenstra | |
| Sun. 18 | 5:30 AM PT6:30 AM MT7:30 AM CT8:30 AM ET12:30 PM GMT13:30 CET12:30 | H | FC Groningen | Philipsstadion | |
| |
| May |
| Sun. 2 | 5:30 AM PT6:30 AM MT7:30 AM CT8:30 AM ET12:30 PM GMT13:30 CET12:30 | A | AZ Alkmaar | DSB Stadion | |
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