| KV Mechelen 2009-2010 |
| August |
| Sat. 1 | 11:00 AM PT12:00 PM MT1:00 PM CT2:00 PM ET6:00 PM GMT20:00 CET19:00 | H | Westerlo | Veolia Stadium Achter de Kazerne | W 4-1 |
| Sun. 9 | 9:00 AM PT10:00 AM MT11:00 AM CT12:00 PM ET4:00 PM GMT18:00 CET17:00 | A | Gent | Jules Otten Stadion | L 1-2 |
| Sat. 15 | 11:00 AM PT12:00 PM MT1:00 PM CT2:00 PM ET6:00 PM GMT20:00 CET19:00 | H | Club Brugge | Veolia Stadium Achter de Kazerne | W 2-1 |
| Sat. 22 | 11:00 AM PT12:00 PM MT1:00 PM CT2:00 PM ET6:00 PM GMT20:00 CET19:00 | A | Germinal Beerschot | Olympisch Stadion | W 3-1 |
| Sat. 29 | 11:00 AM PT12:00 PM MT1:00 PM CT2:00 PM ET6:00 PM GMT20:00 CET19:00 | H | St. Truiden | Veolia Stadium Achter de Kazerne | L 0-2 |
| |
| September |
| Sat. 12 | 11:00 AM PT12:00 PM MT1:00 PM CT2:00 PM ET6:00 PM GMT20:00 CET19:00 | A | Standard Liege | Stade Maurice Dufras | L 0-3 |
| Sat. 19 | 11:00 AM PT12:00 PM MT1:00 PM CT2:00 PM ET6:00 PM GMT20:00 CET19:00 | H | SV Roeselare | Veolia Stadium Achter de Kazerne | W 3-2 |
| Wed. 23 | 11:30 AM PT12:30 PM MT1:30 PM CT2:30 PM ET6:30 PM GMT20:30 CET19:30 | A | Charleroi | Stade du Pays | W 2-1 |
| Mon. 28 | 11:30 AM PT12:30 PM MT1:30 PM CT2:30 PM ET6:30 PM GMT20:30 CET19:30 | A | Cercle Brugge | Jan Breydel Stadion | L 0-1 |
| |
| October |
| Sat. 3 | 11:00 AM PT12:00 PM MT1:00 PM CT2:00 PM ET6:00 PM GMT20:00 CET19:00 | H | Lokeren | Veolia Stadium Achter de Kazerne | W 2-0 |
| Sun. 18 | 9:00 AM PT10:00 AM MT11:00 AM CT12:00 PM ET4:00 PM GMT18:00 CET17:00 | A | Racing Genk | Cristal Arena | W 2-1 |
| Sun. 25 | 12:30 PM PT1:30 PM MT2:30 PM CT3:30 PM ET7:30 PM GMT20:30 CET19:30 | H | Anderlecht | Veolia Stadium Achter de Kazerne | L 0-2 |
| Sat. 31 | 12:00 PM PT1:00 PM MT2:00 PM CT3:00 PM ET7:00 PM GMT20:00 CET19:00 | A | Kortrijk | Guldensporen | L 0-2 |
| |
| November |
| Sat. 7 | 11:00 AM PT12:00 PM MT1:00 PM CT2:00 PM ET7:00 PM GMT20:00 CET19:00 | H | Excelsior Mouscron | Veolia Stadium Achter de Kazerne | L 0-1 |
| Sun. 22 | 9:00 AM PT10:00 AM MT11:00 AM CT12:00 PM ET5:00 PM GMT18:00 CET17:00 | A | Zulte Waregem | Regenboogstadion | L 1-4 |
| Sat. 28 | 11:00 AM PT12:00 PM MT1:00 PM CT2:00 PM ET7:00 PM GMT20:00 CET19:00 | A | Westerlo | Het Kuipje | |
| |
| December |
| Fri. 4 | 11:30 AM PT12:30 PM MT1:30 PM CT2:30 PM ET7:30 PM GMT20:30 CET19:30 | H | Gent | Veolia Stadium Achter de Kazerne | |
| Sat. 12 | 11:00 AM PT12:00 PM MT1:00 PM CT2:00 PM ET7:00 PM GMT20:00 CET19:00 | A | Club Brugge | Jan Breydel Stadion | |
| Sat. 19 | 11:00 AM PT12:00 PM MT1:00 PM CT2:00 PM ET7:00 PM GMT20:00 CET19:00 | H | Germinal Beerschot | Veolia Stadium Achter de Kazerne | |
| Sat. 26 | 11:00 AM PT12:00 PM MT1:00 PM CT2:00 PM ET7:00 PM GMT20:00 CET19:00 | A | St. Truiden | Staaienveld | |
| Wed. 30 | 11:00 AM PT12:00 PM MT1:00 PM CT2:00 PM ET7:00 PM GMT20:00 CET19:00 | H | Charleroi | Veolia Stadium Achter de Kazerne | |
| |
| January |
| Sat. 16 | 11:00 AM PT12:00 PM MT1:00 PM CT2:00 PM ET7:00 PM GMT20:00 CET19:00 | A | SV Roeselare | Schiervelde Stadion | |
| Sat. 23 | 11:00 AM PT12:00 PM MT1:00 PM CT2:00 PM ET7:00 PM GMT20:00 CET19:00 | H | Standard Liege | Veolia Stadium Achter de Kazerne | |
| Sat. 30 | 11:00 AM PT12:00 PM MT1:00 PM CT2:00 PM ET7:00 PM GMT20:00 CET19:00 | H | Cercle Brugge | Veolia Stadium Achter de Kazerne | |
| |
| February |
| Sat. 6 | 11:00 AM PT12:00 PM MT1:00 PM CT2:00 PM ET7:00 PM GMT20:00 CET19:00 | A | Lokeren | Daknam Stadion | |
| Sat. 13 | 11:00 AM PT12:00 PM MT1:00 PM CT2:00 PM ET7:00 PM GMT20:00 CET19:00 | H | Racing Genk | Veolia Stadium Achter de Kazerne | |
| Sat. 20 | 11:00 AM PT12:00 PM MT1:00 PM CT2:00 PM ET7:00 PM GMT20:00 CET19:00 | A | Anderlecht | Constant Vanden Stock | |
| Sat. 27 | 11:00 AM PT12:00 PM MT1:00 PM CT2:00 PM ET7:00 PM GMT20:00 CET19:00 | H | Kortrijk | Veolia Stadium Achter de Kazerne | |
| |
| March |
| Sat. 6 | 11:00 AM PT12:00 PM MT1:00 PM CT2:00 PM ET7:00 PM GMT20:00 CET19:00 | A | Excelsior Mouscron | Stade Le Cannonier | |
| Sat. 13 | 11:00 AM PT12:00 PM MT1:00 PM CT2:00 PM ET7:00 PM GMT20:00 CET19:00 | H | Zulte Waregem | Veolia Stadium Achter de Kazerne | |
| |
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